[HTML][HTML] Hepatitis B flares in chronic hepatitis B: pathogenesis, natural course, and management
ML Chang, YF Liaw - Journal of hepatology, 2014 - Elsevier
Hepatitis B flare, defined as an event with abrupt rise of alanine aminotransferase (ALT)
levels to> 5 times the upper limit of normal during chronic hepatitis B virus (HBV) infection, is
considered to be the result of a human leukocyte antigen-I restricted, cytotoxic T lymphocyte
mediated immune response against HBV and its downstream mechanisms. It may occur
spontaneously, during or after antiviral therapy and in the setting of immunosuppression
and/or chemotherapy. The clinical spectrum of hepatitis B flares varies from asymptomatic to …
levels to> 5 times the upper limit of normal during chronic hepatitis B virus (HBV) infection, is
considered to be the result of a human leukocyte antigen-I restricted, cytotoxic T lymphocyte
mediated immune response against HBV and its downstream mechanisms. It may occur
spontaneously, during or after antiviral therapy and in the setting of immunosuppression
and/or chemotherapy. The clinical spectrum of hepatitis B flares varies from asymptomatic to …