The role of CD47 in neutrophil transmigration: increased rate of migration correlates with increased cell surface expression of CD47
CD47, a cell surface glycoprotein, plays an important role in modulating neutrophil (PMN)
migration across endothelial and epithelial monolayers. Here we show that anti-CD47
monoclonal antibodies (mAbs) delay PMN migration across collagen-coated filters or T84
epithelial monolayers toward the chemoattractant formylmethionylleucylphenylalanine
(fMLP). Despite delayed transmigration by anti-CD47 mAbs, the numbers of PMN migrating
across in either condition were the same as in the presence of control non-inhibitory mAbs …
migration across endothelial and epithelial monolayers. Here we show that anti-CD47
monoclonal antibodies (mAbs) delay PMN migration across collagen-coated filters or T84
epithelial monolayers toward the chemoattractant formylmethionylleucylphenylalanine
(fMLP). Despite delayed transmigration by anti-CD47 mAbs, the numbers of PMN migrating
across in either condition were the same as in the presence of control non-inhibitory mAbs …
