Most studies evaluating immune reconstitution following hematopoietic stem cell
transplantation (HSCT) have focused on immunophenotypic analysis and the capacity of the
immune system to respond to mitogenic stimulation. However, protection against infectious
pathogens and potentially anti-tumor responses correlate with the presence of antigen-
specific immunity, not the immunophenotypic presence of T lymphocytes. Antigen-specific T
lymphocytes present after HSCT can be derived from donor antigen-specific T lymphocytes …