SIRT2 mediates oxidative stress-induced apoptosis of differentiated PC12 cells
H Nie, Y Hong, X Lu, J Zhang, H Chen, Y Li, Y Ma… - …, 2014 - journals.lww.com
Abstract Sirtuin 2 (SIRT2) is a member of the sirtuin family. Previous studies have suggested
that SIRT2 mediates the cell death in models of Parkinson's disease and Huntington's
disease. However, the role of SIRT2 in oxidative stress-induced cell death has remained
unclear. In this study, we investigated the roles of SIRT2 in oxidative stress-induced cell
death using differentiated PC12 cells as a cell model. We found that H 2 O 2 induced a
significant increase in the SIRT2 level in the cells. Both SIRT2 silencing and the SIRT2 …
that SIRT2 mediates the cell death in models of Parkinson's disease and Huntington's
disease. However, the role of SIRT2 in oxidative stress-induced cell death has remained
unclear. In this study, we investigated the roles of SIRT2 in oxidative stress-induced cell
death using differentiated PC12 cells as a cell model. We found that H 2 O 2 induced a
significant increase in the SIRT2 level in the cells. Both SIRT2 silencing and the SIRT2 …
