Bidirectional effects of IL-10+ regulatory B cells in Ldlr−/− mice
H Douna, J Amersfoort, FH Schaftenaar, S Kroon… - Atherosclerosis, 2019 - Elsevier
Background and aims Limiting the pro-inflammatory immune response is critical for the
treatment of atherosclerosis. Regulatory B cells (Bregs) can modulate the immune response
through interleukin-10 (IL-10). Current data regarding Bregs and atherosclerosis is scarce
and conflicting. Methods In this study, we investigated the frequency of IL-10+ B cells during
the development of atherosclerosis in low-density lipoprotein receptor-deficient (Ldlr−/−)
mice and studied the effect of adoptive transfer of IL-10+ B cells on atherosclerosis. Results …
treatment of atherosclerosis. Regulatory B cells (Bregs) can modulate the immune response
through interleukin-10 (IL-10). Current data regarding Bregs and atherosclerosis is scarce
and conflicting. Methods In this study, we investigated the frequency of IL-10+ B cells during
the development of atherosclerosis in low-density lipoprotein receptor-deficient (Ldlr−/−)
mice and studied the effect of adoptive transfer of IL-10+ B cells on atherosclerosis. Results …
