Complications of allogeneic hematopoietic stem cell transplantation (HSCT) remain barriers
to its wider application for a variety of diseases. Graft-versus-host disease (GVHD) is the
major cause of morbidity and mortality following allogeneic HSCT. GVHD can be considered
an exaggerated, undesirable manifestation of a normal inflammatory mechanism, in which
donor lymphocytes encounter foreign antigens in a milieu that fosters inflammation. Recent
advances in the study of cytokine networks, chemokine gradients, and the direct mediators …